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Canine Degenerative Myelopathy: From Gene Mutation Discovery to Clinical Trials

Canine Degenerative Myelopathy: From Gene Mutation Discovery to Clinical Trials

Canine Degenerative Myelopathy: From Gene Mutation Discovery to Clinical Trials

Joan R. Coates, DVM, MS, Diplomate ACVIM (Neurology)
Joan R. Coates, DVM, MS, Diplomate ACVIM (Neurology)
on behalf of VetVine

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$28.00 $ 28.00 $ 28.00

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Launch date: 13 Jan 2020
Expiry Date: 01 Mar 2021

Last updated: 13 Jan 2020

Reference: 195084

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Description

Degenerative myelopathy (DM) is an inherited, adult-onset disease of the spinal cord causing progressive weakness and paralysis of the hind limbs and eventually all limbs. DM has clinical, histopathologic, and genetic parallels to amyotrophic lateral sclerosis (ALS - Lou Gehrig's disease) in humans.

Mutations in an enzyme that converts superoxide to water and hydrogen peroxide, superoxide dismutase 1 (SOD1), have been linked to DM and human ALS. These discoveries have guided studies to further understand natural history, establish biomarkers, and initiate clinical trials for therapeutic strategies.

Join us in this webinar for a better understanding of DM including:

- Genetic testing results as a risk factor for canine degenerative myelopathy
- The neurologic progression in affected patients in terms of disease spread and changes in neuroanatomic localization
- The pathophysiology of the mutated SOD1 protein and its consequences in the multifactorial pathogenesis of canine degenerative myelopathy
- A platform of clinical trial designs and their potential applications in veterinary medicine

Objectives

Understand the genetic testing results as a risk factor for canine degenerative myelopathy
Interpret the neurologic progression in patients affected by canine degenerative myelopathy in terms of disease spread and changes in neuroanatomic localization
Understand the pathophysiology of the mutated SOD1 protein and its consequences in the multifactorial pathogenesis of canine degenerative myelopathy
Learn about a platform clinical trial designs and their potential applications in veterinary medicine
Joan R. Coates, DVM, MS, Diplomate ACVIM (Neurology)

Author Information Play Video Bio

Joan R. Coates, DVM, MS, Diplomate ACVIM (Neurology)
on behalf of VetVine

Dr. Joan Coates is a Full Professor at the College of Veterinary Medicine of the University of Missouri. She currently serves as Service and Section Leader for Neurology & Neurosurgery in the Department of Veterinary Medicine and Surgery. As a veterinary clinical neurologist and neurosurgeon, she is co-directs the Neurology & Neurosurgery Service at the Veterinary Health Center Small Animal Hospital. As a clinician scientist researcher, she is a member of the Comparative Neurology Program at the College of Veterinary Medicine, which explores the inherited developmental and degenerative diseases of the nervous system and is involved with translational research for treatment of neurodegenerative diseases. Her area of research focus involves the study of canine degenerative myelopathy from the perspectives studies of natural history and biomarker development, and clinical trial research on therapeutic strategies.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

  • AAVSB-Registry of Approved Continuing Education (RACE)
  • 1.00 Hours -
    Exam Attempts: 3
    -
    Exam Pass Rate: 70

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