IVECCS 2016 MDR: Prokinetic Pharmacotherapy and the Gastrointestinal Tract

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IVECCS 2016 MDR: Prokinetic Pharmacotherapy and the Gastrointestinal Tract

Diana Hassel, DVM, PhD, DACVS, DACVECC
on behalf of Veterinary Emergency and Critical Care Society

$40.00 ~~$ 40.00~~ ~~$ 40.00~~

$ 40.00 ~~$ 40.00~~ ~~$ 40.00~~

Normal Price: $40.00 $40.00

Review:

Launch date: 01 Nov 2016

Expiry Date:

Last updated: 31 Dec 2020

Reference: 166874

$ 40.00

IVECCS 2016 MDR: Prokinetic Pharmacotherapy and the Gastrointestinal Tract

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Description

This lecture reviews the pertinent anatomy pertaining to regulation of gastrointestinal motility, the physiologic mechanisms controlling motility, the pathophysiology of pathologic ileus, and prokinetic therapy with mechanisms of action.

Objectives

Learn the anatomy pertaining to gastrointestinal motility

The regulation of gastrointestinal motility is governed by both intrinsic and extrinsic input. Intrinsic input comes from the enteric nervous system consisting of the myenteric and submucosal plexi, and the primary extrinsic influences are sympathetic and parasympathetic efferent and afferent neurons.

Learn the physiologic mechanisms controlling gastrointestinal motility

Motility is governed by the complex interaction of the enteric nervous system, the autonomic nervous system, and other endogenous or exogenous mediators such as opioids and prostaglandins. Key neurotransmitters that have excitatory influences on GI smooth muscle include acetylcholine and substance P, whereas inhibitory neurotransmitters include nitric oxide and vasoactive intestinal peptide.

Know the key mechanisms that contribute to pathologic ileus

Ileus can be initiated by multiple disease states including shock, electrolyte imbalances, peritonitis, endotoxemia and ischemia. The underlying pathogenesis for ileus in all of these conditions is inflammation, neurogenic causes, or a combination of the two.

Know the mechanisms of action and sites of action of the most commonly used prokinetic agents

The primary classes of prokinetics include serotonergic agonists/antagonists, dopaminergic antagonists, motilin agonists, acetylcholinesterase inhibitors, sympatholytics and H2 antagonists. Side effects and location of action varies so selection should be based on individual case needs.

Author Information Play Video Bio

Diana Hassel, DVM, PhD, DACVS, DACVECC
on behalf of Veterinary Emergency and Critical Care Society

Associate Professor, Equine Emergency Surgery & Critical Care at Colorado State University. - DVM, PhD, Diplomate ACVS, Diplomate ACVECC - DVM/PhD from University of California, Davis - Special interest areas: Equine colic, equine GI microbiome, endotoxemia, critical care medicine, gastrointestinal physiology.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

AAVSB-Registry of Approved Continuing Education (RACE)
1.00 Hours -
Exam Attempts: 3
-
Exam Pass Rate: 70

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