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2018 ACCP Virtual Journal Club August | Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended‐Release Once‐Daily Tacrolimus Tablets

2018 ACCP Virtual Journal Club August | Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended‐Release Once‐Daily Tacrolimus Tablets

2018 ACCP Virtual Journal Club August | Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended‐Release Once‐Daily Tacrolimus Tablets

Benjamin Philosophe,MD, PhD, Nicolae Leca,MD, Patricia M.West-Thielke, PharmD,Timothy Horwedel, Phar
Benjamin Philosophe,MD, PhD, Nicolae Leca,MD, Patricia M.West-Thielke, PharmD,Timothy Horwedel, Phar
on behalf of American College of Clinical Pharmacology

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Launch date: 09 Aug 2018
Expiry Date: 08 Aug 2021

Last updated: 18 Dec 2018

Reference: 191702

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Description

Learners that complete this course will be able to evaluate and apply a flexible tacrolimus concentration monitoring approach in the management of kidney transplant patients receiving extended‐release once‐daily tacrolimus tablets that allows for an extended therapeutic monitoring window based upon utilization of formulas and tools for interpreting drug levels within the expanded window.

Objectives

Compare the different pharmacokinetic profiles of immediate release and extended-release once-daily tacrolimus formulations.
On completion of this course, the learner will be able to compare the different pharmacokinetic profiles of immediate release and extended-release once-daily tacrolimus formulations.
Describe the correlations between tacrolimus concentrations around trough levels and the overall exposure (plasma drug concentration curve/AUC) over a dosing interval
On completion of this course, the learner will be able to describe the correlations between tacrolimus concentrations around through levels and the overall exposure (plasma drug concentration curve/AUC) over a dosing interval
Interpret non-standard tacrolimus concentration monitoring results and apply these approaches to dosage monitoring/adjustments plans in patients.
On completion of this course, the learner will be able to interpret non-standard tacrolimus concentration monitoring results and apply these approaches to dosage monitoring/adjustments plans in patients.
Benjamin Philosophe,MD, PhD, Nicolae Leca,MD, Patricia M.West-Thielke, PharmD,Timothy Horwedel, Phar

Author Information Play Video Bio

Benjamin Philosophe,MD, PhD, Nicolae Leca,MD, Patricia M.West-Thielke, PharmD,Timothy Horwedel, Phar
on behalf of American College of Clinical Pharmacology

In the 1960s, a group of eminent physicians formulated the concept of an organization dedicated to a new branch of pharmacology that dealt with the effectiveness and safety of drugs in man. As a result of their efforts, the American College of Clinical Pharmacology (ACCP) was founded on September 11, 1969. Today, ACCP consists of a full spectrum of clinical pharmacology professionals from academia, industry, government and clinical settings who span the scope from research and drug development to patient-related care and who remain dedicated to advancing clinical pharmacology with the ultimate goal of enhancing patient care.

As an organization whose primary role is education, ACCP does not concentrate on any one aspect of the discipline. Rather, it seeks to address the educational needs of its diverse membership and all healthcare professionals, covering a range of topics that span the entire area of the interaction between drugs and humans. These areas include, but are not limited to, pharmaceutical chemistry, biochemistry, drug metabolism, pharmacokinetics, pharmacodynamics, pharmacometrics, pharmacogenomics clinical pharmacology practice in the outpatient and inpatient settings, human toxicology, drug interactions and clinical drug trials. The diversity of ACCP is expressed not only in the composition of its membership, but also in its leadership. Maintaining a balance of elected Regents and Officers from all pertinent professional backgrounds ensures that ACCP remains attuned to the needs of all professionals engaged in the practice of or with a strong interest in clinical pharmacology, from the research laboratory (academic and industrial) to the classroom, and from clinical trials to improved patient care.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

  • Accreditation Council for Continuing Medical Education (ACCME)
  • 1.00 Credits

Faculty and Disclosures

Timothy Horwedel

Timothy Horwedel

Timothy Horwedel, MHA, PharmD, BCPS, Transplant Clinical Specialist, Barnes-Jewish Hosp, Dept of Pharmacy, reports a relevant financial relationship
(honoraria, grant support) with Veloxis Pharmaceuticals. An independent content
review has been completed which finds the article and presentation to be
evidence-based, unbiased and non-promotional in nature.
Patricia West-Thielke

Patricia West-Thielke

Patricia West-Thielke, PharmD, Director of Clinical Transplant Research, Univ of
Illinois, Dept of Surgery, reports relevant financial relationships (honoraria, grant
support) with Veloxis Pharmaceuticals and Astellas Pharma US. An independent
content review has been completed which finds the article and presentation to be
evidence-based, unbiased and non-promotional in nature.
Parag Kumar

Parag Kumar

Parag Kumar, PharmD, Associate Director Clinical Pharmacology, Otsuka
America Pharmaceuticals, has nothing to disclose related to this topic.
Sandeep Kushal

Sandeep Kushal

Sandeep Kushal, MBBS, MD, Professor and Head, Dayanand Medical College
and Hosp, Dept of Pharmacology, has nothing to disclose.

Additional Contributors

Conflicts Declared

Conflicts of Interest declaration by Author:

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