Understand normal body fluid physiology
Understand the compartmentalization of fluids in the body and the movement of fluids, electrolytes and macromolecules between compartments. Learn the modified Starling equation and the significance of the endothelial glycocalyx layer.
Understand the derangements in fluid homeostasis in critical illness
Learn the changes in fluid homeostasis secondary to many types of critical illness. Understand both the causes as well as the sequelae of these derangements.
Learn the link between fluid therapy and acute kidney injury
Understand how intravenous fluids can cause acute kidney injury and the causative mechanisms. Both unbalanced crystalloids and synthetic colloids will be the focus.
Understand the mechanism of acid-base derangements
Learn the potential acid-base derangements that can occur secondary to fluid therapy and how they might affect critically ill patients.
Learn how interstitial edema may result from fluid therapy
Understand how fluid therapy can precipitate interstitial edema and its significance in the pathophysiology of organ dysfunction in critically ill animals.