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VCS 2020: The Genetic Basis of Canine Mast Cell Tumors

VCS 2020: The Genetic Basis of Canine Mast Cell Tumors

VCS 2020: The Genetic Basis of Canine Mast Cell Tumors

Heather Gardner
Heather Gardner
on behalf of Missouri Veterinary Medical Association

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Launch date: 22 Nov 2020
Expiry Date:

Last updated: 07 Feb 2021

Reference: 196330

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Description

The behavior of canine mast cell tumors is heterogeneous, associated with a variety of clinical and molecular prognostic factors. The contribution of genetic aberrations has long been recognized in the form of activating KIT gene mutations and altered expression of cellular markers of proliferation. More recently, increased efforts charting the genomic landscape of mast cell tumors have provided fundamental insights into both germline and somatic aberrations associated with this disease. Accumulating evidence highlights themes of structural complexity characterized by recurrent mutations and large structural aberrations, that often parallel the presence of KIT mutations and other clinically relevant prognostic features. These genomic findings provide a blueprint for future investigation, however mechanistic studies are warranted to characterize the functional relevance of mutations and optimize clinical translation of these novel genomic studies. The purpose of this seminar is to examine the spectrum of genetic alterations associated with canine mast cell tumors, discuss current limitations in our understanding of canine mast cell tumor genetics, and explore future directions for application of this knowledge.

Exam offered and MVMA CE certificate issued following presentation.

Objectives

Understand the genetic features of canine mast cell tumors
Understand the biologic significance of molecular and genomic aberrations in mast cell tumors
Obtain an understanding of how evolving genetics data can help fill gaps in knowledge of mast cell tumor biology
Heather Gardner

Author Information Play Video Bio

Heather Gardner
on behalf of Missouri Veterinary Medical Association

Heather Gardner, DVM, PhD, DACVIM (Oncology) is an assistant research professor at the Cummings School of Veterinary Medicine at Tufts University. Dr. Gardner earned her DVM at Washington State University and completed her Residency in Medical Oncology at the Ohio State University before completing her PhD in Genetics at Tufts University. Her research efforts center on comparative and translational oncology, using the tumor genome to inform novel therapeutic approaches.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

  • Missouri Veterinary Medical Association
  • 0.25 Hours -
    Exam Attempts: 3
    -
    Exam Pass Rate: 60

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