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VCS 2020: Medical management of mast cell tumors

VCS 2020: Medical management of mast cell tumors

VCS 2020: Medical management of mast cell tumors

Doug Thamm
Doug Thamm
on behalf of Missouri Veterinary Medical Association

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Review:

Launch date: 22 Nov 2020
Expiry Date:

Last updated: 15 Feb 2021

Reference: 196390

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Latest User Comments

Michelle Wall (3 Dec 2020)
excellent review of medical Tx of MCTs, and good info on Tigilanol Tiglate

I would like to...

Course Availability

This course is only available to trainees days after purchase. It would need to be repurchased by the trainee if not completed in the allotted time period. This course is no longer available. You will need to repurchase if you wish to take the course again.

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Description

Topic: Medical management of mast cell tumors
While surgery remains the mainstay of treatment for canine and feline mast cell tumors (MCTs), there are circumstances where systemic therapy is indicated. These include locally advanced/ disseminated tumors, situations where aggressive local therapy is declined, and adjuvant therapy for tumors at high risk of eventual metastasis. A large number of both traditional cytotoxic and targeted agents have been evaluated for the medical treatment of MCTs; however, there is very little information available regarding efficacy of most treatments when employed postoperatively to delay/prevent local recurrence or metastasis. This lecture will review the data regarding conventional cytotoxic therapies, kinase inhibitors and “frontier” therapies (e.g. monoclonal antibodies, protein kinase C activators) for measurable MCTs in dogs and cats. Combinatorial therapies (e.g. kinase inhibitor/chemotherapy, kinase inhibitor/radiation therapy combinations) will be reviewed. The (limited) information evaluating postoperative therapy will be discussed, and the available data regarding the utility of specialized testing for treatment allocation (e.g. c-¬kit gene mutation testing, KIT protein localization) will be discussed.
Exam offered and MVMA CE certificate issued following presentation.

Objectives

Understand when medical therapy may be indicated for MCT management
Understand the mechanisms of action of common drugs that can be used to treat MCT, appreciate their efficacy, understand the potential adverse effects and know how to monitor patients and how prevent / minimise adverse effects
Be familiar with the data regarding the utility of special molecular tests for assisting in the choice of medical therapy for MCT.
Doug Thamm

Author Information Play Video Bio

Doug Thamm
on behalf of Missouri Veterinary Medical Association

Douglas H. Thamm, VMD, DACVIM (Oncology); Dr. Thamm is the Barbara Cox Anthony Professor of Oncology and Director of Clinical Research at the Colorado State University Flint Animal Cancer Center. He is also a member of the Developmental Therapeutics Section of the University of Colorado Comprehensive Cancer Center and the Cell and Molecular Biology Graduate Program at Colorado State University. Dr. Thamm received his Bachelor’s and VMD degrees from the University of Pennsylvania. He completed an Oncology Residency at the University of Wisconsin, and was a researcher there for 5 additional years before joining the faculty at CSU in 2004.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

  • Missouri Veterinary Medical Association
  • 0.75 Hours -
    Exam Attempts: 3
    -
    Exam Pass Rate: 60

Faculty and Disclosures

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Conflicts Declared

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User Reviews (1)

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Michelle Wall (3 Dec 2020)
excellent review of medical Tx of MCTs, and good info on Tigilanol Tiglate

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