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"Patient is cyanotic yet Echo commonly does not show any significant structural abnormality." one can miss the diagnosis unless you auscultate the chest for continuous murmur (which may not be prominent) or do contrast study.
2.Referring to slide 29, commonest congenital structural abnormality is Bicuspid aortic valve and not VSD.
3.Reference slide 10, unlike PFO,.I think spontaneous closure of ASD is very rare.