2018 ACCP Journal of Clinical Pharmacology Journal CE June | Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics

Jonathan B.Wagner, DO, FAAP, Susan Abdel-Rahman, PharmD, Leon Van Haandel, PhD, Andrea Gaedigk, PhD,
on behalf of American College of Clinical Pharmacology

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Review:

Launch date: 18 Jul 2018

Expiry Date: 01 Jun 2021

Last updated: 16 Apr 2019

Reference: 190956

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2018 ACCP Journal of Clinical Pharmacology Journal CE June | Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics

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Description

Learners that complete this course will be able to identify and interpret the role of genetic variations in drug transporters that influence the pharmacokinetics of simvastatin acid in pediatric patients.

Objectives

Identify specific pathways that play a major role in biotransformation of simvastatin.

On completion of this course, the learner will be able to identify specific pathways that play a major role in biotransformation of simvastatin.

Compare the effect of different genetic variants of drug transporter (SLCO1B1) on systemic exposure of simvastatin in pediatric patients

On completion of this course, the learner will be able to compare the effect of different genetic variants of drug transporter (SLCO1B1) on systemic exposure of simvastatin in pediatric patients.

List the clinical implications of prescribing simvastatin in pediatric patients without any knowledge of their genotype

On completion of this course, the learner will be able to list the clinical implications of prescribing simvastatin in pediatric patients without any knowledge of their genotype

Describe the limitations of using adult kinetic data to determine pediatric doses of simvastatin.

On completion of this course, the learner will be able to describe the limitations of using adult kinetic data to determine pediatric doses of simvastatin.

Author Information Play Video Bio

Jonathan B.Wagner, DO, FAAP, Susan Abdel-Rahman, PharmD, Leon Van Haandel, PhD, Andrea Gaedigk, PhD,
on behalf of American College of Clinical Pharmacology

In the 1960s, a group of eminent physicians formulated the concept of an organization dedicated to a new branch of pharmacology that dealt with the effectiveness and safety of drugs in man. As a result of their efforts, the American College of Clinical Pharmacology (ACCP) was founded on September 11, 1969. Today, ACCP consists of a full spectrum of clinical pharmacology professionals from academia, industry, government and clinical settings who span the scope from research and drug development to patient-related care and who remain dedicated to advancing clinical pharmacology with the ultimate goal of enhancing patient care.

As an organization whose primary role is education, ACCP does not concentrate on any one aspect of the discipline. Rather, it seeks to address the educational needs of its diverse membership and all healthcare professionals, covering a range of topics that span the entire area of the interaction between drugs and humans. These areas include, but are not limited to, pharmaceutical chemistry, biochemistry, drug metabolism, pharmacokinetics, pharmacodynamics, pharmacometrics, pharmacogenomics clinical pharmacology practice in the outpatient and inpatient settings, human toxicology, drug interactions and clinical drug trials. The diversity of ACCP is expressed not only in the composition of its membership, but also in its leadership. Maintaining a balance of elected Regents and Officers from all pertinent professional backgrounds ensures that ACCP remains attuned to the needs of all professionals engaged in the practice of or with a strong interest in clinical pharmacology, from the research laboratory (academic and industrial) to the classroom, and from clinical trials to improved patient care.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

Accreditation Council for Continuing Medical Education (ACCME)
1.00 Credits

Accreditation Council for Pharmacy Education (ACPE)
1.00 Hours -
Exam Pass Rate: 75

Faculty and Disclosures

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