Identify specific pathways that play a major role in biotransformation of simvastatin.
On completion of this course, the learner will be able to identify specific pathways that play a major role in biotransformation of simvastatin.
Compare the effect of different genetic variants of drug transporter (SLCO1B1) on systemic exposure of simvastatin in pediatric patients
On completion of this course, the learner will be able to compare the effect of different genetic variants of drug transporter (SLCO1B1) on systemic exposure of simvastatin in pediatric patients.
List the clinical implications of prescribing simvastatin in pediatric patients without any knowledge of their genotype
On completion of this course, the learner will be able to list the clinical implications of prescribing simvastatin in pediatric patients without any knowledge of their genotype
Describe the limitations of using adult kinetic data to determine pediatric doses of simvastatin.
On completion of this course, the learner will be able to describe the limitations of using adult kinetic data to determine pediatric doses of simvastatin.