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2019 ACCP Virtual Journal Club January | Suggestions for Model‐Informed Precision Dosing to Optimize Neonatal Drug Therapy

2019 ACCP Virtual Journal Club January | Suggestions for Model‐Informed Precision Dosing to Optimize Neonatal Drug Therapy

2019 ACCP Virtual Journal Club January | Suggestions for Model‐Informed Precision Dosing to Optimize Neonatal Drug Therapy

Alexander A Vinks, PhD, PharmD, FCP; Henry T. Akinbi, MD
Alexander A Vinks, PhD, PharmD, FCP; Henry T. Akinbi, MD
on behalf of American College of Clinical Pharmacology

$20.00 $ 20.00 $ 20.00

$ 20.00 $ 20.00 $ 20.00
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Launch date: 22 Feb 2019
Expiry Date: 30 Jan 2022

Last updated: 22 Feb 2019

Reference: 193386

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Course Availability

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Description

Learners that complete this course will understand factors that can influence drug response in premature neonates from a precision medicine perspective. This includes a summary of genetic studies conducted to date in the neonatal population related to drug disposition and response as well as model-based approaches to predict and optimize safe and effective drug exposures.

Objectives

Identify factors contributing to variability in drug disposition and response among preterm and term neonates;
Describe new strategies that might improve the use of therapeutics in treating critically ill neonates;
List barriers to the implementation of precision medicine approaches for critically ill neonates;
Define the role and limitations of pharmacogenomic information to guide dosing in neonates.
Alexander A Vinks, PhD, PharmD, FCP; Henry T. Akinbi, MD

Author Information Play Video Bio

Alexander A Vinks, PhD, PharmD, FCP; Henry T. Akinbi, MD
on behalf of American College of Clinical Pharmacology

Dr. Alexander "Sander" Vinks , PhD, PharmD, FCP, is the Cincinnati Children’s Research Foundation Endowed Chair in Clinical Pharmacology and Professor of Pediatrics & Pharmacology at the Univ of Cincinnati, Coll of Medicine. He is Director of the Div of Clinical Pharmacology and serves as the Program Director of the National Inst of Health Postdoctoral Training Program (T32) in Pediatric Clinical Pharmacology at Cincinnati Children’s Hosp Medical Ctr. He is the Director of Pharmacy Research, Co-director of Cincinnati Children’s Genetic Pharmacology Program and he directs the multidisciplinary Pediatric Pharmacometrics Ctr of Excellence. Dr. Vinks received his academic training at Leiden Univ and the Univ of Toronto. He is a Fellow of the American Coll of Clinical Pharmacology. He is past president of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. Dr. Vinks is Associate Editor for Clinical Pharmacology & Therapeutics and serves on several editorial boards including CPT-Pharmacometrics and Systems Pharmacology. Dr. Vinks' research Interests include systems pharmacology, physiologically-based pharmacokinetics (PBPK), pharmacogenetics/genomics, pharmacokinetic-pharmacodynamic (PK/PD) modeling and the application of population and simulation methods to inform pediatric clinical trial design and therapeutic drug management through the implementation of model-based precision dosing.

Dr. Henry Akinbi is a professor of pediatrics at the University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center. He has been a practicing neonatologist for 25 years. His interest is in neonatal pharmacology, especially as it pertains to drugs commonly used to treat neonatal abstinence syndrome. He also studies toxicology of drugs of abuse and various matrices for assessing intrauterine drug exposure in neonates.

Current Accreditations

This course has been certified by or provided by the following Certified Organization/s:

  • Accreditation Council for Continuing Medical Education (ACCME)
  • 1.00 Credits
  • Accreditation Council for Pharmacy Education (ACPE)
  • 1.00 Hours -
    Exam Pass Rate: 75

Faculty and Disclosures

Jonathan Constance, PhD

Jonathan Constance, PhD

Nothing to disclose
Alexander A. Vinks, PhD, PharmD, FCP

Alexander A. Vinks, PhD, PharmD, FCP

Nothing to disclose
Henry T. Akinbi, MD

Henry T. Akinbi, MD

Nothing to disclose
Sandeep Kaushal, MD

Sandeep Kaushal, MD

Nothing to disclose

Additional Contributors

CE Planner & Moderator: Jonathan Constance, PhD
CE Reviewer: Sandeep Kaushal, MD

Conflicts Declared

Conflicts of Interest declaration by Author:

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